H2N2V1, Main, Exploration, bibRecord, 002B44

The hamster as a model system for the study of influenza vaccines

Identifieur interne : 002B44 ( Main/Exploration ); précédent : 002B43; suivant : 002B45

The hamster as a model system for the study of influenza vaccines

Auteurs : C. W. Potter ; R. Jennings

Source :

Postgraduate Medical Journal [ 0032-5473 ] ; 1976-06.

RBID : ISTEX:26B831C99075A5E860AF72BC302A8EAA6D00D34B

English descriptors

Teeft :
- Animals inoculated, Antibody response, Challenge infection, Challenge virus infection, Detectable serum, Different vaccines, Hamster, Hamster lung suspensions, Hamsters groups, Hamsters inoculated, Heterotypic, Heterotypic immunity, Heterotypic influenza virus infection, Immunization, Infection, Infective virus, Influenza, Influenza vaccine, Influenza vaccines, Influenza virus, Influenza virus infection, Influenza virus vaccine, Influenza virus vaccines, Influenza viruses, Inoculated, Inoculated intranasally, Intranasally, Lung suspensions, Nasal, Nasal washings, Normal hamsters, Serum antibody, Serum antibody response, Surface antigen, Surface antigen material, Titration, Vaccine, Virus, Virus infection, Virus recovery, Whole virus vaccine.

Abstract

A series of experiments was carried out in hamsters to determine their value as an experimental animal for the study of influenza virus infection and immunization. Hamsters could be infected intranasally with approximately 100 EID50 of unadapted influenza A/Port Chalmers/73 virus; infection produced serum HI antibody and virus was recovered from both nasal washings and from lungs. Inoculation of hamsters with influenza virus or inactivated influenza virus vaccine produced immunity to subsequent homologous virus challenge. Groups of hamsters were inoculated with graded doses of a number of different inactivated influenza vaccines: the serum HI antibody response varied greatly for the different vaccines. For some influenza vaccines, the antibody response of hamsters was promoted by prior heterotypic influenza virus infection, but in primed animals the same, wide variation in serum antibody response to different influenza virus vaccines remained. Using the hamster as an experimental model, 60 i.u. of an inactivated A/England/42/72 vaccine gave protection against challenge virus infection; however, 600 i.u. of surface antigen material, including only haemagglutinin and neuraminidase failed to give protection. Inoculation of hamsters with subunit antigens absorbed to alhydrogel gave immunity to challenge virus infection.

Url:

DOI: 10.1136/pgmj.52.608.345

Affiliations:

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<front><div type="abstract" xml:lang="en">A series of experiments was carried out in hamsters to determine their value as an experimental animal for the study of influenza virus infection and immunization. Hamsters could be infected intranasally with approximately 100 EID50 of unadapted influenza A/Port Chalmers/73 virus; infection produced serum HI antibody and virus was recovered from both nasal washings and from lungs. Inoculation of hamsters with influenza virus or inactivated influenza virus vaccine produced immunity to subsequent homologous virus challenge. Groups of hamsters were inoculated with graded doses of a number of different inactivated influenza vaccines: the serum HI antibody response varied greatly for the different vaccines. For some influenza vaccines, the antibody response of hamsters was promoted by prior heterotypic influenza virus infection, but in primed animals the same, wide variation in serum antibody response to different influenza virus vaccines remained. Using the hamster as an experimental model, 60 i.u. of an inactivated A/England/42/72 vaccine gave protection against challenge virus infection; however, 600 i.u. of surface antigen material, including only haemagglutinin and neuraminidase failed to give protection. Inoculation of hamsters with subunit antigens absorbed to alhydrogel gave immunity to challenge virus infection.</div>
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The hamster as a model system for the study of influenza vaccines

The hamster as a model system for the study of influenza vaccines

Source :

English descriptors

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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